Nebraska forced a three-and-out to open the game, before racing 77 yards in just six plays capped by Casey Thompson's 32-yard touchdown strike to wide receiver Trey Palmer to put the Huskers up 7-0 just 3:41 into the game.
Quarterback Chubba Purdy also made his Husker debut in the second half, leading Nebraska on a 13-play, 82-yard scoring drive late in the fourth quarter. Purdy closed out the march with his eight-yard touchdown run to produce the final score.
The rest of game between the historic rivals belonged to Oklahoma.
Nebraska managed 327 total yards, including 164 passing and 163 rushing, but the Sooners piled up 580 total yards, including 312 on the ground and 268 through the air.
Thompson completed 14-of-20 passes for 129 yards and a score for Nebraska, while Purdy completed 7-of-11 attempts for 35 yards, but did throw an interception. Palmer was Nebraska's top target, hauling in a career-high 10 receptions for 92 yards and the opening score.
Gabe Ervin Jr. led the NU ground game with 60 yards on seven second-half carries. Ajay Allen added 49 yards on 11 attempts, while Anthony Grant contributed 36 yards on 13 totes. Purdy pitched in 29 yards on five second-half carries for the Big Red.
Oklahoma quarterback Dillon Gabriel connected on 16-of-27 passes for 230 yards and two touchdowns through the air, while adding six carries for 55 yards including a 61-yard touchdown run in the first quarter to tie the score at 7-7.